Hmmm... yup, geographic culture can be a huge factor and one that doesn't get discussed a whole lot here in terms of the college search. As was briefly touched on in an entertaining fashion earlier in this thread, it can be a bit of a sensitive subject to discuss candidly.
Lousy Lefty, I think there are too many variances to answer the question generally. If you have questions about a specific region and can give more background about the environment your son has grown up in, there are plenty here who can give you specifics and would be more than willing to be candid via PM. Many of us have either lived in various regions and/or had kids experience going to places with very different cultures to play.
Related side note... we run Airbnb out of our house and, due to our location, get tourists from every corner of the country (and world, for that matter). We have fun reading the profiles based on where they live and guess what the personalities are going to be like. Due to regional culture, things tend to be pretty consistent and predictable.
Back to baseball, there are also more and more schools that tap into a recruiting pipeline that includes kids from PR, Dominican Republic, etc. to a varying extent. This probably ties somewhat into what TPM describes. This is a whole other culture that often isn't at all representative of the geographic location of the college, but a factor none the less. One son attended a school with a fair number of these players and at first, there was some friction due to the tendency of that culture to be brash and outspoken (among other things 
). Eventually, he intentionally ended up with two as roomies and good friends.