I don't disagree with checking weather but it is rare to get it in late February. Most direct is 81 and you can stop in Pigeon Forge/Gatlinburg if you have not been or Blue Ridge Parkway runs parallel with it with it only being about a 30-45 drive to get on it at most points. You can still take it part of the way if not the whole way. You will still see some beautiful country. Lived in East Tennessee for 15 years right where you are going through and only had snow 2 times in mid to late February those 15 years. You could always stop in Knoxville and catch a UT weekday game or go to a Vandy weekday game. Should be a good trip any direction you go. PM me if you have specific questions.