Ah, this takes me back to my LL days when I had a couple guys who could always score on the catcher's throw back to the pitcher.
The MLB clip in CoachZ's post is just a bad play by the defense, and the exception that proves the rule that the first and third plays that work on the small diamond with pre-pubesent players will not work on the big diamond with grown men. When you run those plays on the 60' diamond or 70' diamond, you're making the assumption that the defense can't play catch, and that's usually a pretty good assumption. If F1 makes a play on R1 by throwing to F6 or F4, even if there is a rundown and R3 takes off, a grown man (or good HS player) should be able to catch him 99% of the time.