I don't think it matters whether you hold the 2-seamer with the seams running under your fingers, or if you hold it with the 2 seams crossing under your finger tips. You get the same rotation either way.
Bravescoach, as I said, this topic has been debated before.
I view the supposed scientific proofs with a very jaundiced eye. After all, some scientists also claim to have proved that a curve ball doesn't curve, it's just an optical illusion!
I personally have seen rising fastballs. IMHO I know that fastballs can rise. The only remaining question is, why and how?
Some folks confuse their inability to explain the why and how with the notion that it does not or cannot happen. I don't think Einstein or Edison would have approved of that approach. It's really more vanity than science.