Just making something up as I have never seen this in person
Pitcher, SS, 2nd come together in a huddle. 3rd baseman stays put along with 1st baseman and catcher. Have 2nd baseman make a mad dash to tag runner in RF. Hopefully runner on third breaks for home. Then have pitcher (who has the ball the entire time) initiate the run-down at home or 3rd. If 3rd base runner doesn't break then throw out the runner in RF as he is getting chased back to a bag.
Or just ignore it and treat it like any other 1st to 3rd play. Never tried, but I would imagine it would be pretty hard to steal second from RF? Also why wouldn't the pitcher just throw over to 1st once the runner starts to get a lead in a weird direction. Sounds like at that point the runner would have to start moving toward a base?