..........just run the ball. You have the best running back in the game and you have the best running quarterback in the game. Just run the ball.
One timeout with that much time you can get three plays. Run a play, call timeout and in the timeout call two plays. Spread the field to get people out of the box and then run the zone read. This gives you two options to run the ball one each play.
If for whatever reason that you think passing the ball makes sense and you want to run a pick play then have the slot and wide out cross with the slot running a corner route. Yes it takes more time but you either get the TD or overthrow it so it falls incomplete. Throwing over the middle creates too many problems - jumped route (like what happened) or deflected ball gets intercepted because that's where all the defense is playing.