Once again, a great curve ball is a great curve ball. However many RHP will throw very few curveballs to LHH so often they will throw fastballs and changeups mostly. Over the top delivery is a bit tougher on opposite side hitters because they get the best view from 3/4 and lower angles. Leaving curve balls and sliders over the plate to opposite side hitters, especially from RHPs, can result in some tape measure shots.
Back foot, back door, late break, etc. are great if you have a great curve ball or slider. But from an over the top slot the 12-6 will generally have more success against opposite side hitters. Once again, it still depends on how good the 12-6 is. Very much determined by spin rate. I actually believe the great 12-6 breaks later and sharper than more normal curve balls. But the best breaking balls of any type don't get hurt very often.