In theory, the more a pitcher can create angles the better. And of course, the shorter distance is also an advantage. However, this simply doesn't work for most pitchers. To create the most down angle possible a pitcher would need to s throw straight over the top. That slot usually works best for the good 12-6 curve ball, as well. However most pitchers throw from a 3/4 slot. There are many reasons for that which I could mention, but won't take the time now.
The height of the pitcher doesn't always create the shortest distance. Several shorter pitchers have very long strides and some taller pitchers don't. Randy Johnson was one of the tallest and best pitchers in baseball. He threw from a low 3/4 release point with a big angle to the plate. His slider fastball combination had great movement and velocity along with a drastic angle to the plate. Tall with extremely long limbs the ball was coming out of his hand at a different location than any other pitcher. He would create a very different angle along with having a 100 mph fastball and 90+ slider. In other words he used his height in a different way.
All that said, Wacha is a tall pitcher that uses his height to create a severe downward angle. Many pitchers make their living throwing sinkers. The more the ball is thrown down hill to begin with, the harder it becomes to square up anything that sinks. It also helps the high fastball by making it harder to identify early. Big advantage, but not everyone can do it. Most have better control and more movement from a lower arm angle.
To me, for a pitcher to be successful he needs to have one of two things. He either has more "talent" and "intelligence" than other pitchers. Or he needs to be different than everyone else.