We were fortunate enough to go twice (as 10's and 12's), with pretty much the same team. As 10's we finished (literally) around 99 out of 100+ teams (we lost some close games in pool play that killed our record). As 12's we finished 13th out of 100+ teams (got knocked out on back to back wind-blown HRs by the 8 and 9 hitters on a team and lost 2-1). One of the big differences between the two experiences was (us) coaches knowing how the "system" worked up there. By "system" I mean meals, dorms, laundry, etc..
On our first trip we were overwhelmed with the "herding of cats" and getting kids to the dining hall on time, to the cages on time, to the showers on time, getting laundry sorted, etc. That really hindered us in our game preparation and keeping the kids focused. We got stressed by that stuff, and in turn it trickled down to the kids. The second time, we knew what to expect and had our own "systems" in place as to how we would handle that stuff. It worked like clock work and we were able to be more relaxed and focus on the baseball part of it more.
Since you can take a bunch of dads with you as "coaches" I would suggest you do that. It makes life a lot easier to have guys that can be responsible for laundry, escorting kids in and out of dorms, to meals, showers, etc. and allows the "real" coaches to focus on the baseball.
From a baseball perspective, and this is obvious, but play for slaughters by being aggressive early. If you can get out of those games in four innings as opposed to six, it can dramatically save your pitching by the time you get to the end of the week. Also, seeding is everything when you get to the end. Don't sacrifice wins early, just to save pitching for the end. If you get a bad seed...you still won't have enough pitching to go very far.
Finally, something else we did as 12's that was different than 10's was change our expectations. We were a pretty good team and we went up there as 10's to try to "win it all". We put undue pressure on ourselves and the kids, and that didn't work. The second time, we went up there with the idea of just letting these kids have the times of their lives and make some memories they wouldn't forget. We figured if we took the pressure off, the baseball would take care of itself...and it did. We had a blast that second time. My HS senior that just graduated still says if he could do anything over again it would be to do that week again.
Go up there with the goal of having the best week of your life with your son (assuming you have a kid on the team) or with the kids you are coaching. Laugh at the craziness, don't stress and get your kids stressed, and truly truly have a great time. Don't let where you finish impact the experience for the kids...seriously, just have fun.