I'm considered one of the covid vaccine hesitant. I don't have any issues with vaccines, esp growing up in Asia. I'm conservative but never been political about vaccines. I was troubled by all the pushback and resistance to mask mandates/guidelines for example. Masks are an inconvenience that I don't have a problem of putting on regardless of whether I believe in it's effectiveness or not.
However, putting something in our body is a different issue altogether. I've been trying to read up a lot on the vaccines, trying to get beyond the rhetorics and soundbites. It's been hard to find objective information. The article below is the best I've found that describes the story of the R&D of the mRNA technology, how it works, and the process of developing a marketable medical treatment out of it. The end result is that it justifies my concerns.
https://www.statnews.com/2020/...-covid-vaccine-race/
The issue isn't the technology itself (I find it very intriguing and exciting). The issue is that there has never been any drugs or treatment that has been developed and used in the real world using this technology until the covid vaccines. There's a lot of exciting possibilities. But if not for the covid emergency, it probably would still have taken years for a drug/treatment based on this new technology to be tried in the real world. And even then, it will be done initially in very small scope.
Some of the questions that comes to my (non medically trained) mind are:
1. Is there an off switch for this mRNA (once enough spike proteins are created) and does the off switch work all the time?
2. Are we dealing with this with too large of a hammer by training our bodies to reject all spike proteins? Are there going to be something in the future that we realize our bodies need that has the spike protein, and by the it's too late bec our bodies are trained to reject it?
3. What if a particle/virus/etc in the future that would have been harmless to human becomes widespread but has the same spike protein? If our bodies have been trained to develop an immune response to all particles with spike protein, could this inadvertently result in a unnecessary allergic (or worse yet, a fatal cytokine storm) in our bodies (much like how pollen produces reaction in some people but not others)?
4. Are there any other unintended consequence that we haven't thought of that when we find out, it would have been too late as there's no way to reverse the instructions we've already programed to our immune systems.
I know we don't want to turn this into a vaccine and/or covid discussion, but I think the story is inherently about that. I do agree that we should keep it as objective as possible and refrain from political and inflammatory rhetorics.
One excerpt from the article:
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Some experts worry about injecting the first vaccine of this kind into hundreds of million of people so quickly.
“You have all these odd clinical and pathological changes caused by this novel bat coronavirus, and you’re about to meet it with all of these vaccines with which you have no experience,” said Paul Offit, an infectious disease expert at Children’s Hospital of Philadelphia and an authority on vaccines.
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I do recognize that this article was written back in Nov 2020. This person may have changed his mind now after seeing all the clinical trials and real world result. But it doesn't change the validity of his initial concerns. The result so far at least shows there's minimal short terms negative results. But I don't think we have enough info yet to conclude that there's no unintended long term impact.