In contrast to the above, JAMA came out with an online paper yesterday. A supplement table in the study compared the outcome of approx 16,000 vaccinated people (without immune system issues) who developed breakthrough infections versus over 2 million unvaccinated but also healthy people who developed an infection during the pandemic.
Breakthrough cases were much more common than the original CDC estimates and occurred in 5 % of all vaccinated people. Notably after Delta, the rate was actually 7%.
Of the vaccinated, breakthrough cases, 16 percent required hospitalization. In comparison, 23 percent of the unvaccinated were hospitalized.
0.7 of the vaccinated breakthrough patients had serious outcomes, including death, compared to 1.9 percent of the unvaccinated patients.
The median time from vaccination to breakthrough infection was 138 days.
Older age, female sex, and a higher number of comorbidities were significantly associated with a higher likelihood of breakthrough infection. Specifically, risk for breakthrough infection increased by 30% to 40% among patients 30 years or older compared with those aged 18 to 29 years.
I think with Omicron the breakthrough rate is going to be MUCH higher than 7%.
Clearly vaccination confers benefit even in otherwise healthy people. But it is not magic which is going to do away with COVID.